April 13, 2021 — After receiving stories of a uncommon blood clot in folks receiving the Johnson & Johnson COVID-19 vaccine, the FDA and the CDC have beneficial a pause in the usage of the vaccine, pending additional investigation.
Right here, what you want to know:
Why was the pause recommended?
After reviewing knowledge, the companies discovered six stories of people that skilled uncommon blood clots together with low platelets, that are the smallest blood cells and concerned in clotting. The six stories have been discovered of greater than 6.8 million doses given. The FDA and CDC initiated the pause ”out of an abundance of warning.”
What else is thought?
In line with a joint assertion issued by the CDC and FDA, all six circumstances have been in ladies between ages 18-48. Signs occurred 6-13 days after vaccination. The kind of clot is thought medically as a cerebral venous sinus thrombosis (CVST) and was seen together with low ranges of blood platelets. Go right here to study extra about all these blood clots.
Of the six circumstances, one lady died; one other was in essential situation.
Remedy of the sort of clot is totally different from that for different varieties, the CDC and FDA say. Sometimes, an anticoagulant drug, heparin, is used. However for the sort of clot, different therapy could also be wanted.
Why does it occur?
“We do not have a definitive reply presently, however it seems to contain an immune response associated to the J&J vaccine that adversely impacts the operate of the platelets, which in flip prevents the traditional clotting course of from occurring,” says Robert Glatter, MD, emergency physician at Lenox Hill Hospital in New York Metropolis.
He says that the reason “might finally be associated to the adenovirus vector [used in the vaccine] itself.”
Why does it appear to have an effect on ladies greater than males?
That’s not but identified, says William Schaffner, MD, professor of preventive drugs and infectious illness specialist at Vanderbilt College Medical Middle in Nashville. “This has been true for the AstraZeneca [vaccine] as nicely and their blood clot points,” he says. Whether it is an immune-related concern, ladies do are inclined to have extra of these points than males, typically, he says.
What ought to individuals who acquired the J&J vaccine know and do?
Remember that the stories of blood clots have been uncommon, Schaffner suggests. The possibilities are about 1 in one million, primarily based on the six stories out of 6.8 million doses given. “That is truly a testomony to the sensitivity of our vaccine security system,” he says, that these few stories can be detected out of tens of millions of doses.
Individuals who have gotten the vaccine needs to be vigilant of signs, the FDA and CDC say. Should you obtained the Johnson & Johnson vaccine and develop extreme headache, belly ache, leg ache, or shortness of breath inside 3 weeks of vaccination, contact your their well being care supplier.
How lengthy will the pause final?
That can be not but identified. The CDC’s Advisory Committee on Immunization Practices (ACIP) will meet on Wednesday to additional evaluate the circumstances and ”assess their potential significance.” FDA can be reviewing the information additional.