AsianScientist (Oct. 5, 2020) – One of many two antibodies within the cocktail used to deal with US president Donald Trump for COVID-19 was developed utilizing blood samples from three sufferers in Singapore. REGN-COV2, a mixture of two antibodies in opposition to the SARS-CoV-2 spike protein, was developed by US-based biotechnology firm Regeneron. Two papers describing preclinical research of REGN-COV2 have been printed in Science.
Convalescent plasma from sufferers who’ve recovered from COVID-19 may include protecting antibodies that can be utilized to both stop or deal with the illness. Though the US Meals and Drug Administration has licensed the emergency use of convalescent plasma to deal with COVID-19, the problem of acquiring enough blood from volunteers signifies that it’s not potential to make use of it at a big scale.
As a substitute of counting on giant quantities of convalescent plasma, Regeneron cloned SARS-CoV-2 binding antibodies from each ‘humanized’ mice and recovered COVID-19 sufferers to provide a dependable supply of monoclonal antibodies. Whereas the humanized mice have been primarily based on a expertise owned by Regeneron, the human plasma used was provided via an settlement with Singapore’s Nationwide Centre for Infectious Ailments. In keeping with a commentary printed in The Straits Instances in Might, there have been talks for Singapore to doubtlessly take part in additional scientific trials of the therapy.
On September 29, 2020, Regeneron introduced optimistic knowledge from a Section 1 trial of 275 sufferers, displaying that REGN-COV2 diminished viral ranges and improved signs. Shortly after, on October 2, 2020, it was revealed that Trump had acquired a excessive dose of the experimental remedy, which has not acquired emergency use approval however was administered below a compassionate use request.
The articles could be discovered at:
Hansen et al. (2020) Research in Humanized Mice and Convalescent People Yield a SARS-CoV-2 Antibody Cocktail.
Baum et al. (2020) Antibody Cocktail to SARS-CoV-2 Spike Protein Prevents Fast Mutational Escape Seen with Particular person Antibodies.
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